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Invitrogen™ Kinesin 5B Polyclonal Antibody
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Catalog No. PA1643
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100 μg
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PA1643 100 μg
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Catalog No. PA1643 Supplier Invitrogen™ Supplier No. PA1643
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Description

Rabbit Polyclonal Antibody

PA1-643 detects kinesin 5B from mouse and human samples. This antibody is specific for kinesin 5B and does not detect other kinesin isotypes. PA1-643 has been successfully used in Western blot and immunofluorescent procedures. By Western blot, this antibody detects an ~110 kDa protein representing kinesin 5B protein. The PA1-643 immunizing peptide corresponds to amino acid residues 376-396 from human kinesin 5B. This sequence is 95% and 90% conserved for mouse and rat, respectively. This peptide (Cat. # PEP-198) is available for use in neutralization and control experiments.

Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Kinesin 5B
Applications Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1 mg/mL BSA and 0.05% sodium azide
Gene KIF5B
Gene Accession No. P33176, Q2PQA9, Q61768
Gene Alias AL022807; Conventional kinesin heavy chain; EMBL:ABC25059.1}; epididymis secretory protein Li 61; HEL-S-61; Khc; Khcs; KIF5A; KIF5B; kif5b {ECO:0000312; kinesin 1 (110-120kD); kinesin family member 5A; kinesin family member 5B; kinesin heavy chain; kinesin heavy chain member 5B, ubiquitous; kinesin-1 heavy chain; KINH; KNS; Kns1; ubiquitous kinesin heavy chain; UKHC; U-KHC; Unknown (protein for IMAGE:7944745)
Gene Symbols KIF5B
Host Species Rabbit
Immunogen Synthetic Peptide: C I(376) D E Q F D K E K A N L E A F T V D K D I(396).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117550, 16573, 3799
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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