Invitrogen™ KIR2DL5A/KIR2DL5B Polyclonal Antibody

Catalog No.	Quantity
PIPA568460	100 μL

Catalog No. PIPA568460 Supplier Invitrogen™ Supplier No. PA568460

Description

Rabbit Polyclonal Antibody

Predicted to react with Human samples.

KIR2DL5A and KIR2DL5B are Killer cell immunoglobulin-like receptors (KIRs), transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. KIR proteins are thought to play an important role in regulation of the immune response. Functionally, KIR2DL5A and KIR2DL5B are receptors on natural killer (NK) cells for HLA-C alleles and prevent cell lysis by inhibiting the activity of NK cells.

Specifications

• Antigen: KIR2DL5A/KIR2DL5B
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: KIR2DL5A
• Gene Accession No.: Q8N109, Q8NHK3
• Gene Alias: CD158 antigen-like family member F2; CD158F; CD158F1; CYB561; CYB561A1; Cytochrome b561; cytochrome b-561; cytochrome b561 family, member A1; ferric-chelate reductase 2; FRRS2; killer cell Ig-like receptor; killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A; killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B; killer cell immunoglobulin-like receptor 2DL5A; killer cell immunoglobulin-like receptor 2DL5B; killer cell immunoglobulin-like receptor 2DLX; killer cell immunoglobulin-like receptor KIR2DL5A; killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 5; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5B; killer Ig receptor; killer-cell Ig-like receptor; KIR2DL5; KIR2DL5.1; KIR2DL5.2; KIR2DL5.3; KIR2DL5A; KIR2DL5B; KIR2DLX
• Gene Symbols: KIR2DL5A, KIR2DL5B
• Host Species: Rabbit
• Immunogen: Synthesized peptide derived from human KIR2DL5A/KIR2DL5B [aa 121-170].
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 553128, 57292
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

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