Invitrogen™ KLB Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA544023

Catalog No. PIPA544023

Description

Peptide sequence: DAYTIRRGLF YVDFNSKQKE RKPKSSAHYY KQIIRENGFS LKESTPDVQG Sequence homology: Cow: 100%; Dog: 93%; Guinea Pig: 85%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 86%; Rat: 100%.

KLB is a single-pass type III membrane protein. It contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. KLB is probably inactive as a glycosidase. It increases the ability of FGFR1 and FGFR4 to bind FGF21.

Specifications

• Antigen: KLB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KLB
• Gene Alias: AV071179; Betakl; betaKlotho; beta-klotho; BKL; Klb; Klb-ps1; klotho beta; klotho beta like; klotho beta, pseudogene 1; klotho beta-like protein; MGC142213; RGD1308227
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 152831
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q86Z14
• Gene Symbols: KLB
• Immunogen: Synthetic peptide directed towards the middle region of human KLB.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG