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Invitrogen™ KLF15 Polyclonal Antibody
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Catalog No. PIPA5115478
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PIPA5115478 100 μL
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Catalog No. PIPA5115478 Supplier Invitrogen™ Supplier No. PA5115478
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total KLF15.

KLF15 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. A transcriptional activator, KLF15 binds to the GA element of the CLCNKA promoter and may help to regulate the strict tissue and nephron segment-specific expression of CLCNKA and CLCNKB channel genes. It plays an essential role in adipogenesis in cells through its regulation of PPARG expression. Reports suggest that KLF15 is an inhibitor of cardiac hypertrophy and functions in a pathway, regulating the cardiac response to hemodynamic stress, and regulates mitochondrial acetyl-CoA synthase expression in skeletal muscle. KLF15 may also act as a transcriptional repressor of the rhodopsin and IRBP promoters in the retina, and is a possible participant in repression of photoreceptor-specific gene expression in nonphotoreceptor cells. It is highly expressed in liver, followed by heart, skeletal muscle, and kidney but not expressed in bone marrow or lymphoid tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KLF15
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene KLF15
Gene Accession No. Q9EPW2, Q9UIH9
Gene Alias 1810013I09Rik; AV048136; AW494632; Cardiovascular Krueppel-like factor; CKLF; DKFZp779M1320; Kidney-enriched krueppel-like factor; kidney-enriched Kruppel-like factor; KKLF; KKLF protein; Klf15; KLF15; transcription factor; Krueppel-like factor 15; Kruppel like factor 15; Kruppel-like factor 15
Gene Symbols KLF15
Host Species Rabbit
Immunogen A synthesized peptide derived from human KLF15(Accession Q9UIH9), corresponding to amino acid residues M1-H33.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 28999, 66277, 85497
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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