Invitrogen™ KLHL21 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531730

Catalog No. PIPA531730

Description

Recommended positive controls: A549, HeLa, Jurkat, Raji. Predicted reactivity: Mouse (95%), Rat (94%), Xenopus laevis (80%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.

Specifications

• Antigen: KLHL21
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KLHL21
• Gene Alias: 1810045K06Rik; D330008A20; kelch like family member 21; kelch-like 21; kelch-like family member 21; kelch-like protein 21; KIAA0469; Klhl21; MGC99635; mKIAA0469; RGD1305863
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9903
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.84 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9UJP4
• Gene Symbols: KLHL21
• Immunogen: Recombinant fragment corresponding to a region within amino acids 345 and 560 of Human KLHL21.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov