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KLKB1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Catalog No. p-7212245 Shop All Proteintech Group Inc Products
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50-173-5802 150 μL
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Catalog No. 50-173-5802 Supplier Proteintech Group Inc Supplier No. 279911AP150UL
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Description

Rabbit Polyclonal Antibody

The antigen of this antibody just cover the heavy chain of KLKB1, so this antibody cannot recognize the light chain.

Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.

Specifications

Antigen KLKB1
Applications Western Blot
Classification Polyclonal
Concentration 0.33 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene KLKB1
Gene Accession No. P03952, P14272, P26262
Gene Alias Fletcher factor, Kininogenin, KLK3, KLKB1, Plasma kallikrein, Plasma prekallikrein, PPK
Gene Symbols KLKB1
Host Species Rabbit
Immunogen KLKB1 Fusion Protein Ag27491
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16621, 25048, 3818
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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