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Tocris Bioscience™ Klotho-derived peptide 1
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Catalog No. 78301
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78-301 1 mg
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Catalog No. 78-301 Supplier Tocris Bioscience™ Supplier No. 7830/1
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Description

TGF-β receptor 2 (TβR2) binding peptide; disrupts the TGF-β/TβR2 interaction

Klotho-derived peptide 1 (KP1) is a peptide that binds to TGF-β receptor 2 (TβR2) (Kd = 1.4 μM). It inhibits TGF-β signaling by blocking TGF-β/TβR2 interaction. In mouse models of renal fibrosis, intravenous injection of KP1 results in its specific accumulation in the injured kidneys. It suppresses TGF-β signaling, repressing fibroblast activation and ameliorates kidney fibrosis in vivo.

Specifications

Gene ID (Entrez) 9365
Purity 95%
Content And Storage Store at -20°C
Gene Alias EC 3.2.1, EC 3.2.1.31, KL, klotho, TGFB2, TGFbeta, TGFbeta 2
Molecular Weight (g/mol) M.W. (Observed): 3228.48
Quantity 1 mg
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