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Invitrogen™ Klotho Polyclonal Antibody
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Catalog No. PIPA521078
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100 μg
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Catalog No. Quantity
PIPA521078 100 μg
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Catalog No. PIPA521078 Supplier Invitrogen™ Supplier No. PA521078
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Description

Rabbit Polyclonal Antibody

A suggested positive control is HepG2 cell lysate. PA5-21078 can be used with blocking peptide PEP-1192.

KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Klotho
Applications Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene KL
Gene Accession No. O35082, Q9UEF7, Q9Z2Y9
Gene Alias alpha-kl; HFTC3; Kl; Klotho; Klotho peptide; secreted form of Klotho protein
Gene Symbols KL
Host Species Rabbit
Immunogen A 17 amino acid peptide near the center of human KLOTHO.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16591, 83504, 9365
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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