KMT2E (MLL5) Polyclonal Antibody, Active Motif™

Catalog No.	Quantity
50-199-3407	10 μL
50-199-3406	100 μL

Catalog No. 50-199-3407 Supplier Active Motif Supplier No. 61448

Description

Rabbit Polyclonal Antibody

The mixed lineage leukemia (MLL) gene family comprise a group of Histone H3 lysine 4 (H3K4) methyltransferases within the larger SET1 family. The founding member MLL commonly undergoes translocations in infantile leukemia and displays increased expression in some adult myeloid leukemias. MLL2, also designated ALR, exists within a complex of proteins. MLL2 is important for mouse embryonic development and may be involved in adhesion-related cytoskeletal events affecting cell growth and survival. The MLL2 gene maps to the human locus 19q13.1, which is a frequent target of rearrangement or amplification in solid tumors. MLL3 or its paralogue MLL4 associate with activating signal cointegrator-2 (ASC-2), which regulates ligand-dependent H3K4 trimethylation and expression of LXR-target genes. MLL3 maps to a location on human chromosome 7 that is often deleted in myeloid disorders. MLL3 also exhibits higher expression in peripheral blood, placenta, pancreas, testis, and fetal thymus. MLL5 localizes to the nucleus and forms intranuclear protein complexes, which may regulate chromatin remodeling and cellular growth suppression. The gene encoding human MLL5 lies within chromosome band 7q22.3, a region deleted in cytogenetic aberrations of acute myeloid malignancies.

Specifications

• Antigen: KMT2E (MLL5)
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: Lot-Specific
• Conjugate: Unconjugated
• Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
• Gene: KMT2E
• Gene Accession No.: Q3UG20, Q8IZD2
• Gene Alias: 1810033J14Rik; 9530077A04Rik; D230038D11Rik; HDCMC04P; histone-lysine N-methyltransferase 2E; histone-lysine N-methyltransferase MLL5; Inactive histone-lysine N-methyltransferase 2E; Inactive lysine N-methyltransferase 2E; KMT2E; lysine (K)-specific methyltransferase 2E; lysine methyltransferase 2E; lysine N-methyltransferase 2E; MGC70452; Mll5; myeloid/lymphoid or mixed-lineage leukemia 5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); Myeloid/lymphoid or mixed-lineage leukemia protein 5; Myeloid/lymphoid or mixed-lineage leukemia protein 5 homolog; NKp44L
• Gene Symbols: KMT2E
• Host Species: Rabbit
• Immunogen: This antibody was raised against a peptide within human kMT2E (MLL5).
• Purification Method: Antigen affinity chromatography
• Quantity: 10 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 55904, 69188
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG