Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

KU 0060648, Tocris Bioscience™

Click to view available options
Quantity:
10mg
50mg
This item is not returnable. View return policy
881375-00-4
C33H34N4O4S
582.719
AATCBLYHOUOCTO-UHFFFAOYSA-N
2-4-ethylpiperazin-1-yl-n-4-2-morpholino-4-oxo-4h-chromen-8-yl dibenzo b,d thiophen-1-yl acetamide,2-4-ethylpiperazin-1-yl-n-4-2-morpholin-4-yl-4-oxochromen-8-yl dibenzothiophen-1-yl acetamide,d0r0tw,ku hplc,2-4-ethylpiperazin-1-yl-n-6-2-morpholin-4-yl-4-oxo-4h-chromen-8-yl-8-thiatricyclo 7.4.0.0?,? trideca-1 13 ,2,4,6,9,11-hexaen-3-yl acetamide,2-4-ethylpiperazin-1-yl-n-6-2-morpholin-4-yl-4-oxochromen-8-yl-8-thiatricyclo 7.4.0.0 2 ,? trideca-1 9 ,2 7 ,3,5,10,12-hexaen-3-yl acetamide,4-ethyl-n-4-2-4-morpholinyl-4-oxo-4h-1-benzopyran-8-yl-1-dibenzothienyl-1-piperazineacetamide,n-4-2-morpholino-4-oxo-4h-1-benzopyran-8-yl dibenzothiophene-1-yl-4-ethylpiperazine-1-acetamide
11964036
2-(4-ethylpiperazin-1-yl)-N-[4-(2-morpholin-4-yl-4-oxochromen-8-yl)dibenzothiophen-1-yl]acetamide
CCN1CCN(CC1)CC(=O)NC2=C3C4=CC=CC=C4SC3=C(C=C2)C5=CC=CC6=C5OC(=CC6=O)N7CCOCC7
This item is not returnable. View return policy
881375-00-4
C33H34N4O4S
582.719
AATCBLYHOUOCTO-UHFFFAOYSA-N
2-4-ethylpiperazin-1-yl-n-4-2-morpholino-4-oxo-4h-chromen-8-yl dibenzo b,d thiophen-1-yl acetamide,2-4-ethylpiperazin-1-yl-n-4-2-morpholin-4-yl-4-oxochromen-8-yl dibenzothiophen-1-yl acetamide,d0r0tw,ku hplc,2-4-ethylpiperazin-1-yl-n-6-2-morpholin-4-yl-4-oxo-4h-chromen-8-yl-8-thiatricyclo 7.4.0.0?,? trideca-1 13 ,2,4,6,9,11-hexaen-3-yl acetamide,2-4-ethylpiperazin-1-yl-n-6-2-morpholin-4-yl-4-oxochromen-8-yl-8-thiatricyclo 7.4.0.0 2 ,? trideca-1 9 ,2 7 ,3,5,10,12-hexaen-3-yl acetamide,4-ethyl-n-4-2-4-morpholinyl-4-oxo-4h-1-benzopyran-8-yl-1-dibenzothienyl-1-piperazineacetamide,n-4-2-morpholino-4-oxo-4h-1-benzopyran-8-yl dibenzothiophene-1-yl-4-ethylpiperazine-1-acetamide
11964036
2-(4-ethylpiperazin-1-yl)-N-[4-(2-morpholin-4-yl-4-oxochromen-8-yl)dibenzothiophen-1-yl]acetamide
CCN1CCN(CC1)CC(=O)NC2=C3C4=CC=CC=C4SC3=C(C=C2)C5=CC=CC6=C5OC(=CC6=O)N7CCOCC7

Dual DNA-PK and PI 3-K inhibitor

Dual PI 3-K and DNA-PK inhibitor (IC50 values are <0.1, 0.5, 4 and 19 nM for PI 3-Kδ, PI 3-Kβ, PI 3-Kα and DNA-PK respectively). Inhibits proliferation of MCF7 cells in vitro and delays growth of MCF7 xenografts in mice. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency ∽2 to 4-fold, and decreases nonhomologous end-joining (NHEJ) frequency ∽40%; maximum effect seen at 250 nM.
Quantity 50mg
Formula Weight 582.71
Percent Purity >97%
Chemical Name or Material KU 0060648

Recommended Storage : Store at -20°C