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  5. Tocris Bioscience™ L Moses dihydrochloride

Tocris Bioscience™ L Moses dihydrochloride
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Catalog No. 625110
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62-511-0 10 mg
62-515-0 50 mg
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Catalog No. 62-511-0 Supplier Tocris Bioscience™ Supplier No. 6251/10
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Description

High affinity and selective PCAF bromodomain inhibitor

L Moses dihydrochloride is a high affinity and selective cell-permeable p300/CBP-associated factor (PCAF) inhibitor (Ki = 47 nM), which exhibits no significant activity against a panel of 48 other bromodomains except GCN5 (Kd = 600 nM). L Moses exhibits >4500-fold selectivity for PCAF over BRD4. The compound inhibits Tunicamycin (Cat. No. 3516) -induced neuronal cell death by reversing the transcriptional changes associated with Tunicamycin treatment. L Moses exhibits metabolic stability in mouse and human liver microsomes and no observable cytotoxicity in peripheral blood mononuclear cells (PBMC).

Specifications

Chemical Name or Material (1S, 2S)-N1,N1-Dimethyl-N2-(3-methyl-1,2,4-triazolo[3,4-a]phthalazin-6-yl)-1-phenylpropane-1,2-diamine dihydrochloride
Assay Percent Range >98%
Quantity 10 mg
Molecular Formula C21H24N6.2HCl
Formula Weight Observed MW: 433.38
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