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Tocris Bioscience™ L189

Catalog No. 356110R
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Quantity:
10 mg
50 mg
Catalog No. Quantity
35-611-0R 10 mg
35-615-0R 50 mg
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This item is not returnable. View return policy

Catalog No. 35-611-0R

Supplier: Tocris Bioscience™ 3561/10

This item is not returnable. View return policy

Description

DNA ligase I, III and IV inhibitor

L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki = 5 μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.

Specifications

Quantity 10 mg
Product Type L189
Molecular Weight (g/mol) 246.29
Inhibitors L189

For Research Use Only

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