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Tocris Bioscience™ L189

DNA ligase I, III and IV inhibitor

Supplier: Tocris Bioscience™ 3561/10

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Catalog No. 35-611-0R

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Description

L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki = 5 μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.

Specifications

Quantity	10 mg
Product Type	L189
Molecular Weight (g/mol)	246.29
Inhibitors	L189

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Tocris Bioscience™ L189

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