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Enzo Life Sciences Lactacystin (1 mg) CAS: 133343-34-7
Supplier: Enzo Life Sciences BMLPI1041000
Key inhibitor for use in proteasome research. A potent and selective irreversible proteasome inhibitor. Specifically inhibits 20S proteasome (MCP; multicatalytic complex). Blocks proteasome activity by targeting the catalytic β-subunit. Has no effect on serine or cysteine proteases. Induces apoptosis inhuman monoblast U937 cells. Inhibits NF-κB activation by inhibiting IκB degradation (IC50=10 µM). Inhibits the ubiquitin proteasome pathway in cell culture. Inhibits cathepsin A. Upregulates HSP70 and HSP22, suggesting an initial neuroprotective pathway. Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells. Formula: C15H24N2O7S. MW: 376.4. Source: Synthetic.
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