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Invitrogen™ Lamin A/C Monoclonal Antibody (3A6-4C11), eBioscience™

Catalog No. 14984782
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14-984-782 100 μg
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Catalog No. 14-984-782 Supplier Invitrogen™ Supplier No. 14984782
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Mouse Monoclonal Antibody

Description: This 3A6-4C11 monoclonal antibody recognizes human and mouse Lamin A and Lamin C - two splice variants of the LMNA gene. The 3A6-4C11 antibody has been also reported to cross-react with rat Lamin A/C. Applications Reported: This 3A6-4C11 antibody has been reported for use in western blotting and immunocytochemistry. Applications Tested: This 3A6-4C11 antibody has been tested by western blotting of human and mouse cell line lysates. This may be used at 0.5 μg/mL.

Lamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. The LMNA gene has been linked to many disorders of the muscular system, nervous system, and the fat distributions systems including: Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Lamin A/C
Applications Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 3A6-4C11
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene LMNA
Gene Accession No. P02545, P48678
Gene Alias 70 kDa lamin; cb948; CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; I79_009616; IDC; lamin; lamin A; lamin A/C; lamin A/C L homeolog; lamin A/C-like 1; Lamin A+C mutant; Lamin AC; lamin a-c; lamin C; lamin C2; lamin-A; Lamin-A/C; LDP1; LFP; LGMD1B; LMN1; lmna; LMNA protein; lmna.L; lmna-A; LMNC; LMNL1; mutant 453W; Mutant lamin A/C; nuclear intermediate filament protein; nuclear lamin A; prelamin-A/C; PRO1; progerin mutant; Renal carcinoma antigen NY-REN-32; RP11-54H19.1; unnamed protein product; wu:fk66d12; XELAEV_18040808mg
Gene Symbols LMNA
Host Species Mouse
Immunogen Recombinant fragment of human Lamin A.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16905, 4000
Target Species Human, Mouse
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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