Lamin A/C Monoclonal Antibody (Jol3), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA15820

Catalog No. 01-674-927

Description

MA1-5820 reacts with human dermal fibroblasts in immunocytochemistry. Other cell/tissue types have not been tested in this application. It reacts with human, mouse and rat samples in Western blot. This antibody recognizes the common tail domain of Lamin A+C, epitope aa 464-572.

Lamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. The LMNA gene has been linked to many disorders of the muscular system, nervous system, and the fat distributions systems including: Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).

Specifications

• Antigen: Lamin A/C
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: tissue culture supernatant with 0.1% sodium azide
• Gene Accession No.: P02545, P48678, P48679
• Gene Symbols: LMNA
• Immunogen: Recombinant bacterially expressed full length protein
• Regulatory Status: RUO
• Gene ID (Entrez): 16905, 4000, 60374
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ChIP Assay, Immunocytochemistry, Western Blot
• Clone: Jol3
• Conjugate: Unconjugated
• Gene: LMNA
• Gene Alias: 70 kDa lamin; cb948; CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; I79_009616; IDC; lamin; lamin A; lamin A/C; lamin A/C L homeolog; lamin A/C-like 1; Lamin A+C mutant; Lamin AC; lamin a-c; lamin C; lamin C2; lamin-A; Lamin-A/C; LDP1; LFP; LGMD1B; LMN1; lmna; LMNA protein; lmna.L; lmna-A; LMNC; LMNL1; mutant 453W; Mutant lamin A/C; nuclear intermediate filament protein; nuclear lamin A; prelamin-A/C; PRO1; progerin mutant; Renal carcinoma antigen NY-REN-32; RP11-54H19.1; unnamed protein product; wu:fk66d12; XELAEV_18040808mg
• Host Species: Mouse
• Quantity: 1 mL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov