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Invitrogen™ Lamin A Monoclonal Antibody (4A4-A4), eBioscience™
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Catalog No. 502550876
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50-255-0876 100 μg
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Catalog No. 50-255-0876 Supplier Invitrogen™ Supplier No. 14984882
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Description

Mouse Monoclonal Antibody

Description: This 4A4-A4 monoclonal antibody recognizes human and mouse mature Lamin A. Applications Reported: This 4A4-A4 antibody has been reported for use in western blotting, immunocytochemistry and immunoprecipitation. Applications Tested: This 4A4-A4 antibody has been tested by western blotting of human cell line lysates. This may be used at 0.2 μg/mL. This 4A4-A4 antibody has also been tested by immunocytochemistry on A549 cells. This may be used at 0.06 μg/mL.

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
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Specifications

Antigen Lamin A
Applications Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 4A4-A4
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene LMNA
Gene Accession No. P02545, P48678
Gene Alias 70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A; lamin A/C; lamin A/C-like 1; lamin C; lamin C2; lamin-A/C; LDP1; LFP; LGMD1B; LMN1; Lmna; LMNA protein; LMNC; LMNL1; OTTHUMP00000015843; OTTHUMP00000015846; OTTHUMP00000015847; Prelamin-A/C; PRO1; renal carcinoma antigen NY-REN-32; unnamed protein product
Gene Symbols LMNA
Host Species Mouse
Immunogen KLH-conjugated peptide corresponding to the C-terminus of human Lamin A.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16905, 4000
Target Species Human, Mouse
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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