Invitrogen™ Lamin A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA581211

Catalog No. PIPA581211

Description

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Human LMNA.

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.

Specifications

• Antigen: Lamin A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LMNA
• Gene Alias: 70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A; lamin A/C; lamin A/C-like 1; lamin C; lamin C2; lamin-A/C; LDP1; LFP; LGMD1B; LMN1; Lmna; LMNA protein; LMNC; LMNL1; OTTHUMP00000015843; OTTHUMP00000015846; OTTHUMP00000015847; Prelamin-A/C; PRO1; renal carcinoma antigen NY-REN-32; unnamed protein product
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 4000
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: P02545
• Gene Symbols: LMNA
• Immunogen: A synthetic peptide corresponding to the N-terminus of the Human LMNA/lamins A.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG