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Invitrogen™ Lamin B2 Monoclonal Antibody (E-3), Alexa Fluor™ 555
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Catalog No. PIMA33210AZ
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50 μL
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PIMA33210AZ 50 μL
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Catalog No. PIMA33210AZ Supplier Invitrogen™ Supplier No. MA332100A555
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Description

Mouse Monoclonal Antibody

Lamin B2 Monoclonal Antibody for ICC/IF

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
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Specifications

Antigen Lamin B2
Applications Immunocytochemistry
Classification Monoclonal
Clone E-3
Concentration 1 mg/mL
Conjugate Alexa Fluor 555
Formulation PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.4
Gene LMNB2
Gene Accession No. P14732, P21619, Q03252
Gene Alias EPM9; fc15d06; im:7142331; LAMB2; lamin; lamin A/C; lamin B2; lamin B2 S homeolog; lamin B3; lamin-B2; Lamin-L(II); LMN2; LMNA; lmnb2; lmnb2.S; lmnb2-a; lmnb2-b; MGC2721; RGD1563803; unnamed protein product; wu:fb94e05; wu:fb95e12; wu:fc15d06; wu:fc49h03; XELAEV_18009631mg
Gene Symbols LMNB2
Host Species Mouse
Immunogen Extracts from chicken nuclei.
Purification Method Protein A
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16907, 299625, 396222, 84823
Target Species Chicken, Human, Mouse, Rat
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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