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LAP (Latency Associated peptide) Mouse anti-Human, Functional Grade, Clone: VB3A9, eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

$98.25 - $183.00

Specifications

Antigen LAP (Latency Associated peptide)
Clone VB3A9
Target Species Human
Conjugate Functional Grade
Isotype IgG1
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-147-85 Non-distribution product as customer accommodation.
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Invitrogen
16982380
25 μg
Each for $98.25
Add to cart
 
50-147-86 Non-distribution product as customer accommodation.
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Invitrogen
16982382
100 μg
Each for $183.00
Add to cart
 
Description

Description

Description: This VB3A9 monoclonal antibody recognizes human latency-associated peptide (LAP), also known as the TGF-beta propeptide. Human LAP is a homodimer of 65-75 kDa that is non-covalently associated with TGF-beta and this complex is also referred to as the small latent complex (SLC). LAP can be covalently associated with latent TGF-beta binding proteins (LTBP) through disulfide bonds, forming the large latent complex (LLC). The association of LAP with TGF-beta facilitates its secretion and also renders TGF-beta inactive. VB3A9 has been reported to cross-react with non-human primate LAP, but does not cross-react with mouse LAP. Applications Reported: This VB3A9 antibody has been reported for use in immunoblotting (WB) and immunoprecipitation. Applications Tested: This VB3A9 antibody has been tested by immunoblot analysis of human platelets under reducing conditions at 5 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay. Storage and handling: Use in a sterile environment. Filtration: 0.2 µm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC.

TGF beta-1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its prodomain. Activation of TGF-b1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF-beta, an aminoterminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP.
Specifications

Specifications

LAP (Latency Associated peptide)
Human
IgG1
Monoclonal
Liquid
Antibody
4° C
VB3A9
Functional Grade
Immunoprecipitation, Western Blot
Primary
Monoclonal
PBS with no preservative; pH 7.2
RUO
SDS

For Research Use Only.

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