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Invitrogen™ Lass4 Polyclonal Antibody
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Catalog No. PIPA5113620
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100 μL
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PIPA5113620 100 μL
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Catalog No. PIPA5113620 Supplier Invitrogen™ Supplier No. PA5113620
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MLYSFMKKGQ MEKDIRSDVE ESDSSEEAAA AQEPLQLKNG AAGGPRPAPT For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. Predicted homology: Cow: 86%; Dog: 93%; Horse: 93%; Human: 100%; Mouse: 92%; Pig: 100%; Rabbit: 93%; Rat: 100%.

The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they are all involved in sphingolipid synthesis. LASS4 is a 394 amino acid endoplasmic reticulum, multi-pass membrane protein. LASS4 increases the levels of long ceramides such as C22:0- and C24:0-ceramides. In cells deficient for CLN9, as observed in neuronal ceroid lipofuscinosis (NCL) or Batten disease, LASS4 can increase ceramide levels and partially correct growth and apoptosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Lass4
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene CERS4
Gene Accession No. Q9HA82
Gene Alias 2900019C14Rik; Ceramide synthase 4; CerS4; FLJ12089; LAG1 homolog, ceramide synthase 4; LAG1 longevity assurance homolog 4; Lass4; longevity assurance homolog 4; Sphingosine N-acyltransferase CERS4; TRAM homolog 1; translocating chain-associating membrane protein homolog 1; Trh1
Gene Symbols CERS4
Host Species Rabbit
Immunogen Synthetic peptide directed towards the C terminal region of human LASS4 (aa 326-375).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79603
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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