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Invitrogen™ Lass6 Polyclonal Antibody
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Catalog No. PIPA520648
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100 μg
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PIPA520648 100 μg
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Catalog No. PIPA520648 Supplier Invitrogen™ Supplier No. PA520648
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Description

Rabbit Polyclonal Antibody

A suggested positive control is rat brain tissue lysate. PA5-20648 can be used with blocking peptide PEP-0768. The immunogen is located within the last 50 amino acids of LASS6.

Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family. Five mammalian homologs have been reported, and the corresponding proteins have previously been investigated with respect to their key role in ceramide synthesis. However, members of the LAG family have been shown to be involved in cell growth regulation and cancer differentiation. May be involved in sphingolipid synthesis or its regulation. Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Localized to nuclear membrane a multi-pass membrane protein, may be expressed on endoplasmic reticulum membrane. Glycosylation on Asn-18 is not necessary for function. Like other LAG family members, the LASS6 protein contained a homeodomain and LAG1 domain. Lass6 displays highest homology to LASS5. The corresponding gene was localized to human chromosome 2q24.3, spanning a rather large genomic region of 318 kb. Sequences in mouse and zebrafish suggested a conservation of LASS6 in vertebrates because the protein and corresponding genomic sequences are highly conserved. LASS6 was shown to be broadly expressed in a wide range of tissues. Recent data suggested a role in cancer differentiation and early embryonic development.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Lass6
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene CERS6
Gene Accession No. Q6ZMG9, Q8C172
Gene Alias 4732462C07Rik; AW544719; Ceramide synthase 6; CERS5; CerS6; LAG1 homolog, ceramide synthase 6; LAG1 longevity assurance homolog 6; LASS6; longevity assurance homolog 6; MGC129949; MGC129950; RGD1561599; T1L
Gene Symbols CERS6
Host Species Rabbit
Immunogen A 13 amino acid synthetic peptide near the carboxy terminus of the human LASS6.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 241447, 253782, 366065
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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