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Invitrogen™ Layilin Polyclonal Antibody
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Catalog No. PIPA5114008
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PIPA5114008 100 μL
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Catalog No. PIPA5114008 Supplier Invitrogen™ Supplier No. PA5114008
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: CYKVIYFHDT SRRLNFEEAK EACRRDGGQL VSIESEDEQK LIEKFIENLL For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. Predicted homology: Cow: 91%; Dog: 92%; Guinea Pig: 85%; Horse: 92%; Human: 100%; Rabbit: 93%; Rat: 86%; Mouse: 79%;.

Layilin is a cell surface receptor encoded by the LAYN gene, known for its involvement in cell adhesion and motility processes. It is a member of the C-type lectin-like domain protein family and plays a crucial role in mediating interactions with the extracellular matrix. Layilin is associated with cytoskeletal reorganization, impacting cellular processes such as shape change, migration, and stabilization of cell-matrix contacts. It has been shown to interact with other proteins like talin, contributing to the linkage between the cell membrane and the actin cytoskeleton, which is vital for maintaining cell structure and facilitating movement. Layilin's role in cell adhesion and motility makes it significant in developmental processes and wound healing. Additionally, dysregulation of layilin expression has been implicated in cancer metastasis, where altered adhesive properties and increased motility contribute to tumor progression and dissemination. Research is ongoing to explore the detailed mechanisms of layilin's function and its potential as a target for therapeutic intervention in diseases characterized by abnormal cell migration and adhesion.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Layilin
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene LAYN
Gene Accession No. Q6UX15
Gene Alias E030012M19Rik; FLJ30977; FLJ31092; Gm511; layilin; LAYN; LYAN; RGD1564444; UNQ208/PRO234
Gene Symbols LAYN
Host Species Rabbit
Immunogen Synthetic peptide directed towards the N terminal region of human LAYN (aa 49-98).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 143903
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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