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Invitrogen™ Layilin Polyclonal Antibody
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Catalog No. PA551089
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PA551089 100 μL
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Catalog No. PA551089 Supplier Invitrogen™ Supplier No. PA551089
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Description

Rabbit Polyclonal Antibody

Layilin Polyclonal Antibody detects endogenous levels of Layilin protein.

Layilin is a cell surface receptor encoded by the LAYN gene, known for its involvement in cell adhesion and motility processes. It is a member of the C-type lectin-like domain protein family and plays a crucial role in mediating interactions with the extracellular matrix. Layilin is associated with cytoskeletal reorganization, impacting cellular processes such as shape change, migration, and stabilization of cell-matrix contacts. It has been shown to interact with other proteins like talin, contributing to the linkage between the cell membrane and the actin cytoskeleton, which is vital for maintaining cell structure and facilitating movement. Layilin's role in cell adhesion and motility makes it significant in developmental processes and wound healing. Additionally, dysregulation of layilin expression has been implicated in cancer metastasis, where altered adhesive properties and increased motility contribute to tumor progression and dissemination. Research is ongoing to explore the detailed mechanisms of layilin's function and its potential as a target for therapeutic intervention in diseases characterized by abnormal cell migration and adhesion.
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Specifications

Antigen Layilin
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 0.5% BSA and 0.02% sodium azide; pH 7.4
Gene LAYN
Gene Accession No. Q6UX15, Q8C351
Gene Alias E030012M19Rik; FLJ30977; FLJ31092; Gm511; layilin; LAYN; LYAN; RGD1564444; UNQ208/PRO234
Gene Symbols LAYN
Host Species Rabbit
Immunogen Synthesized peptide derived from the Internal region of human Layilin (aa 71-120).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 143903, 244864, 500996
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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