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LB 42708, Tocris Bioscience™

Catalog No. 429450
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Catalog No. Quantity
42-945-0 50 mg
42-941-0 10 mg
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Catalog No. 42-945-0 Supplier R&D Systems Supplier No. 4294/50
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Description

Selective farnesyltransferase (FTase) inhibitor

Selective inhibitor of farnesyltransferase (FTase). Blocks farnesylation of H-Ras, N-Ras and K-Ras4B (IC50 values are 0.8, 1.2 and 2.0 nM respectively). Displays >50,000-fold selectivity for FTase over geranylgeranyltransferase (GGTase) I. Inhibits VEGF-induced Ras activation; suppresses angiogenesis in vivo and in vitro (IC50 = 75 nM). Orally active.

Chemical Identifiers

CAS 226929-39-1
Molecular Formula C30H27BrN4O2
Molecular Weight (g/mol) 555.476
InChI Key GUUIRIMAQGOLHT-UHFFFAOYSA-N
Synonym d02kvr, 1-1-4-bromobenzyl-1h-imidazol-5-yl methyl-4-naphthalen-1-yl-1h-pyrrol-3-yl morpholino methanone, 1-1-4-bromophenyl methyl-1h-imidazol-5-yl methyl-4-1-naphthalenyl-1h-pyrrol-3-yl-4-morpholinylmethanone, 1-3-4-bromophenyl methyl imidazol-4-yl methyl-4-naphthalen-1-ylpyrrol-3-yl-morpholin-4-ylmethanone, 4-1-1-4-bromophenyl methyl-1h-imidazol-5-yl methyl-4-1-naphthalenyl-1h-pyrrol-3-yl carbonyl morpholine, 4-1-1-4-bromophenyl methyl-1h-imidazol-5-yl methyl-4-naphthalen-1-yl-1h-pyrrole-3-carbonyl morpholine, 4-1-3-4-bromophenyl methyl imidazol-4-yl methyl-4-naphthalen-1-yl pyrrole-3-carbonyl morpholine
PubChem CID 10099206
IUPAC Name [1-[[3-[(4-bromophenyl)methyl]imidazol-4-yl]methyl]-4-naphthalen-1-ylpyrrol-3-yl]-morpholin-4-ylmethanone
SMILES C1COCCN1C(=O)C2=CN(C=C2C3=CC=CC4=CC=CC=C43)CC5=CN=CN5CC6=CC=C(C=C6)Br

Specifications

Quantity 50 mg
Formula Weight 555.46
Percent Purity >98%
Chemical Name or Material LB 42708

Safety and Handling

Recommended Storage Desiccate at Room Temperature
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