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Invitrogen™ LDLR Polyclonal Antibody
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Catalog No. PIPA546987 Shop All Thermo Scientific Products
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PIPA546987 100 μg
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Catalog No. PIPA546987 Supplier Invitrogen™ Supplier No. PA546987
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Description

Goat Polyclonal Antibody

In direct ELISAs, approximately 10% cross-reactivity with recombinant human LDL R is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LDLR
Applications Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Neutralization, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene LDLR
Gene Accession No. P35951
Gene Alias FH; FHC; Hlb301; I79_005860; LDL receptor; LDLA; LDLCQ2; LDLR; ldl-r; LDLRA; low density lipoprotein receptor; low density lipoprotein receptor protein; low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3
Gene Symbols LDLR
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant mouse LDL R Ala22-Arg790 (Ala23Val, Cys27Gly).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16835
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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