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Genscript Corporation Antibody Protein Proteins Proteins 200 UG 1/EA
Supplier: Genscript Corporation Z02962200
Leptin is a cytokine belonging to the Interleukin 6 family and has a four-helix bundle structure. Leptin is encoded by the ob gene and produced and secreted by white adipose tissue. The receptors of Leptin are Type I cytokine receptors which exist in two different forms: a short form expressed in multiple tissues and a long form expressed exclusively in the central nervous system (CNS). Upon binding to Leptin the receptors activate the JAK/STAT3 pathway and PI3K and stimulate transcriptional programs that regulate feeding behavior metabolic rate endocrine axes and glucose fluxes. The deficiency of Leptin in human and mouse causes morbid obesity diabetes and neuroendocrine anomalies. Leptin also has effects on reproduction and immunity. In summary Leptin is a pivotal cytokine controlling energy balance and as such has profound effects on human health.
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