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Invitrogen™ Leptin Polyclonal Antibody
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Catalog No. 01674447
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500 μg
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Catalog No. Quantity
01-674-447 500 μg
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Catalog No. 01-674-447 Supplier Invitrogen™ Supplier No. PA19571
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Description

Chicken Polyclonal Antibody

PA1-9571 detects Leptin in mouse and rat samples. PA1-9571 has been successfully used in Western blot and ELISA procedures. By Western blot, PA1-9571 detects a 16 kDa protein representing Leptin. PA1-9571 immunogen is a purified recombinant rat Leptin protein.

Leptin is a 167 amino acid long protein hormone with important effects in regulating body weight, metabolism and reproductive function. Leptin is approximately 16 kDa in mass and encoded by the obese (ob) gene. Leptin is expressed predominantly by adipocytes, which fits with the idea that body weight is sensed as the total mass of fat in the body. Smaller amounts of leptin are also secreted by cells in the epithelium of the stomach and in the placenta. Leptin receptors are highly expressed in areas of the hypothalamus known to be important in regulating body weight, as well as in T lymphocytes and vascular endothelial cells. Leptin's effects on body weight are mediated through effects on hypothalamic centers that control feeding behavior and hunger, body temperature and energy expenditure. Leptin is involved in regulating food intake, energy expenditure, and adiposity through hypothalamic leptin receptors. Leptin promotes hematopoiesis, angiogenesis, wound healing, inflammation, immune responses, influences pubertal development and fetal growth. Studies have investigated the role of leptin in obesity, anorexia nervosa, insulin resistance, and hypertension. Leptin also has thermogenic actions and regulates enzymes of fatty acid oxidation. Severe hereditary obesity in rodents and humans can be caused by defects in leptin production.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Leptin
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Lep
Gene Accession No. P41160, P50596
Gene Alias CD295 antigen; H-Leptin; HuB219; Lep; LEPD; LEP-R; Leptin; leptin (murine obesity homolog); leptin (obesity homolog, mouse); leptin precursor; Method: conceptual translation supplied by author.; OB; obese; obese protein; obese, mouse, homolog of; obesity; obesity factor; obesity protein; OB-R; OBS; truncated leptin
Gene Symbols Lep
Host Species Chicken
Immunogen Purified recombinant rat Leptin protein.
Purification Method IgY fraction
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16846, 25608
Target Species Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgY
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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