Invitrogen™ Leptin Receptor Monoclonal Antibody (2F1)

Catalog No.	Quantity
FERMA549058	100 μg

Catalog No. FERMA549058 Supplier Invitrogen™ Supplier No. MA549058

Description

Mouse Monoclonal Antibody

The monoclonal antibody 2F1 specifically reacts with sLR with a molecular mass of 180kD. The 2F1 antibody can be used to measure in both free sLR and sLR bound to leptin in plasma.

The leptin (OB-R) receptor is a member of the cytokine receptor superfamily which plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of the OB-R by the adipose tissue-secreted hormone, leptin, appears to activate downstream signaling events through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Leptin can homo-dimerize OB-R extracellular domains while downstream signaling events are initiated upon homo-dimerization of OB-R intracellular domains. Several isoforms of the OB-R which differ in length and signaling capabilities have been reported. RNA transcripts encoding the OB-R long form have been found in the choroid plexus and in the hypothalamus which has been proposed as a control center for satiety and energy expenditure. Mutations in either the mouse OB-R (db) or leptin (ob) genes have been shown to result in early-onset obesity. Metabolic abnormalities attributable to these genotypes include hypercorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered CNS activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue.

Specifications

• Antigen: Leptin Receptor
• Applications: Inhibition Assays, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: 2F1
• Concentration: 100 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.1% BSA and 0.02% sodium azide
• Gene: Lepr
• Gene Accession No.: P48357
• Gene Alias: B219; CD antigen CD295; CD295; CD295 antigen; db; diabetes; Fa; HuB219; HuB219.2; LEPR; LEP-R; Leprb; LEPRD; LEPROT; leptin receptor; Leptin receptor (fatty); leptin receptor gene-related protein; Modb1; OB receptor; obese-like; obl; Obr; OB-R; OB-RGRP
• Gene Symbols: Lepr
• Host Species: Mouse
• Immunogen: The monoclonal antibody 2F1 reacts with human soluble leptin receptor (sLR) in plasma.
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3953
• Target Species: Human
• Content And Storage: 4°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1