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Invitrogen™ LFG Polyclonal Antibody
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Catalog No. PIPA596520
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100 μL
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PIPA596520 100 μL
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Catalog No. PIPA596520 Supplier Invitrogen™ Supplier No. PA596520
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MTQGKLSVAN KAPGTEGQQQ VHGEKKEAPA VPSAPPSYEE ATSGEGMKAG AFPPAPTAVP LHPSWAYVDP SSSSSYDNGF PTGDHELFTT FSWDDQKVRR VFVRK; Positive Samples: Mouse brain; Cellular Location: Cell junction, Cell membrane, Membrane raft, Multi-pass membrane protein, postsynaptic cell membrane, synapse.

LFG, a seven transmembrane spanning protein, is a recently identified member of a family whose members can inhibit apoptotic cell death induced by Fas receptor. LFG is a human homolog of rat NMP35 and consists of a conserved transmembrane domain and a small cytoplasmic domain. Reports have shown that LFG protects the cell from Fas-mediated neuronal cell death in a novel way. LFG binds to Fas receptor but doesn't have any effect in reducing Fas expression or decreasing the ability of FADD binding to the receptor. Furthermore, LFG doesn't protect the cells from TNF-alpha mediated cell death process. Although LFG is ubiquitously expressed, Northern blot analysis detected an increased expression in hippocampus and other neural tissues, suggesting a protective role in neurodegenerative diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LFG
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.93 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene FAIM2
Gene Accession No. Q8K097
Gene Alias 2900002L20Rik; FAIM2; Fas apoptotic inhibitory molecule 2; fas apoptotic inhibitory molecule 2; protein lifeguard 2; Kiaa0950; Lfg; LFG2; lifeguard; neural membrane protein 35; NGP35; NMP25; Nmp35; protein lifeguard; protein lifeguard 2; TMBIM2; transmembrane BAX inhibitor motif-containing protein 2
Gene Symbols FAIM2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-105 of human FAIM2 (NP_0364382).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 72393
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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