Invitrogen™ LFG Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA141589

Catalog No. 01-675-208

Description

LFG Polyclonal Antibody for Western Blot, IHC (P), Flow

LFG, a seven transmembrane spanning protein, is a recently identified member of a family whose members can inhibit apoptotic cell death induced by Fas receptor. LFG is a human homolog of rat NMP35 and consists of a conserved transmembrane domain and a small cytoplasmic domain. Reports have shown that LFG protects the cell from Fas-mediated neuronal cell death in a novel way. LFG binds to Fas receptor but doesn't have any effect in reducing Fas expression or decreasing the ability of FADD binding to the receptor. Furthermore, LFG doesn't protect the cells from TNF-alpha mediated cell death process. Although LFG is ubiquitously expressed, Northern blot analysis detected an increased expression in hippocampus and other neural tissues, suggesting a protective role in neurodegenerative diseases.

Specifications

• Antigen: LFG
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FAIM2
• Gene Alias: 2900002L20Rik; FAIM2; Fas apoptotic inhibitory molecule 2; fas apoptotic inhibitory molecule 2; protein lifeguard 2; Kiaa0950; Lfg; LFG2; lifeguard; neural membrane protein 35; NGP35; NMP25; Nmp35; protein lifeguard; protein lifeguard 2; TMBIM2; transmembrane BAX inhibitor motif-containing protein 2
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 23017, 246274, 477613, 72393
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.0 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: O88407, Q8K097, Q9BWQ8
• Gene Symbols: FAIM2
• Immunogen: Synthetic peptide corresponding to residues 1-50 of humanLifeguard.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Canine, Monkey
• Product Type: Antibody
• Isotype: IgG