Invitrogen™ Ligelizumab Recombinant Monoclonal Antibody

Catalog No.	Quantity
MA559500	1 mg
MA559499	100 μg

Catalog No. MA559500 Supplier Invitrogen™ Supplier No. MA559500

Description

Recombinant Monoclonal Antibody

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.

IgE is one of the five classes of immunoglobulins found in mammals, characterized by its monomeric structure consisting of two heavy (epsilon) chains with four Ig-like constant domains and two light chains. Although IgE comprises only a small portion of the total immunoglobulin in serum, it plays a crucial role in type I hypersensitivity reactions, such as hay fever, asthma, hives, and anaphylactic shock. IgE is produced by terminally differentiated plasma B cells and basophils. It binds to Fc epsilon receptors on mast cells and basophils, leading to the release of histamine and other molecules that promote allergic responses. Crosslinking of IgE bound to these receptors induces degranulation of mast cells and basophils, resulting in allergic manifestations. In addition to its role in allergic responses, IgE is functionally important for immunity against parasites, highlighting its dual role in both protective and pathological immune processes.

Specifications

• Antigen: Human IgE (Ligelizumab Biosimilar)
• Applications: ELISA, Flow Cytometry, Functional Assay, Surface Plasmon Resonance
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: 25mM histidine with 0.01% Tween 80, 8% sucrose and no preservative; pH 6.2
• Gene: IGHE
• Gene Accession No.: P01854
• Gene Alias: HCAK1; IgA1; IgG3; IGHA1; IGHA2; IGHG1; IGHG2; IGHG3; IGHG4; IGKC; IGKCD; IGLC; IGLC1; Immunoglobulin E; immunoglobulin heavy constant alpha 1; immunoglobulin heavy constant alpha 2 (A2m marker); immunoglobulin heavy constant gamma 1 (G1m marker); immunoglobulin heavy constant gamma 2 (G2m marker); immunoglobulin heavy constant gamma 3 (G3m marker); immunoglobulin heavy constant gamma 4 (G4m marker); immunoglobulin kappa constant; immunoglobulin lambda constant 1; ImmunoglobulinE; Km
• Gene Symbols: IGHE
• Host Species: Human
• Purification Method: Protein A
• Quantity: 1 mg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3497
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG1