Invitrogen™ LIMP2 Recombinant Superclonal™ Antibody

Catalog No.	Quantity
71-207-2	100 μg

Catalog No. 71-207-2 Supplier Invitrogen™ Supplier No. 712072

Description

Rabbit Recombinant Superclonal Antibody

This antibody is predicted to react with Monkey, Bovine, Pig Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called 'Recombinant polyclonal antibody', this product is now rebranded as 'Recombinant Superclonal™ antibody'. The physical product and the performance remain unchanged.

High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII differs from SR-BI in that the encoded c-terminal cytoplasmic domain is almost completely different. SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with an approximately 4-fold lower efficiency than SR-BI. Nuclease protection assays show SR-BII to be abundant in mouse tissues expressing SR-BI, with SR-BII expression found in liver, adrenal glands, and testes. Although the role of SR-BII is not completely clear, research suggests that it may be a functional HDL receptor. In addition, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with the SR-BII isoform mediating selective transfer of lipid between HDL and cells. The relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.

Specifications

• Antigen: LIMP2
• Applications: Western Blot, Immunocytochemistry
• Classification: Recombinant Superclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene: SCARB2
• Gene Accession No.: O35114, Q14108
• Gene Alias: 85 kDa lysosomal membrane sialoglycoprotein; 85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2; 9330185J12Rik; AMRF; CD 36; CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II); CD36 antigen-like 2; CD36 molecule; Cd36l2; EPM4; HLGP85; I79_021583; LGP85; LIMP II; LIMP2; LIMP-2; LIMPII; Lysosome membrane protein 2; lysosome membrane protein II; MLGP85; Scarb2; Scavenger receptor class B member 2; scavenger receptor class B, member 2; sCD 36; sCD36; soluble CD 36; soluble CD36; SR-B2; SR-BII
• Gene Symbols: SCARB2
• Host Species: Rabbit
• Immunogen: Protein corresponding to human LIMP2 [aa35-aa430].
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 12492, 950
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG