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Invitrogen™ LIN7A Monoclonal Antibody (P879)

Catalog No. PIMA518305
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100 μL
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PIMA518305 100 μL
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Catalog No. PIMA518305 Supplier Invitrogen™ Supplier No. MA518305
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Description

Mouse Monoclonal Antibody

Recommended positive controls: MCF-7, MDA-MB-231. Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (97%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LIN7A
Applications Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone P879
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene LIN7A
Gene Accession No. O14910
Gene Alias AI848705; hLin-7; lin 7 homolog a; LIN7; lin-7 homolog A (C. elegans); lin-7 homolog A, crumbs cell polarity complex component; Lin7a; lin-7A; lin-7-Ba; Mals1; MALS-1; mammalian LIN-7 1; mammalian lin-seven protein 1; mLin-7; protein lin-7 homolog A; Tax interaction protein 33; TIP-33; Veli; Veli1; veli-1; veli-1 protein; vertebrate homolog of C. elegans Lin-7 type 1; vertebrate LIN7 homolog 1; vertebrate lin-7 homolog 1
Gene Symbols LIN7A
Host Species Mouse
Immunogen Recombinant protein encompassing a sequence within the center region of human LIN7A. The exact sequence is proprietary.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8825
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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