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Enzo Life Sciences LL-Z1640-2 (1mg). CAS: 66018-38-0
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Supplier:  Enzo Life Sciences ALX380267M001

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Inhibitor of the JNK/p38 pathways. Inhibits anisomycin-induced but not TNF-induced JNK/p38 activation. Potent protein kinase inhibitor.A naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC50 = 8nM) in an ATP-competitive and irreversible manner; also inhibits MEK1 (IC50 = 411nM) and three other MAPKKKs (IC50 ≥268 nM against MEKK1, ASK1, and MEKK4) but at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H2O2-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells. Alternative name: (5Z)-7-Oxozeaenol. Purity: ≥95% (HPLC). Appearance: White to off-white solid. Solubility: Soluble in methanol, acetone, DMSO (up to 25mM) or ethyl acetate; insoluble in ethanol and n-hexane. Long Term Storage: -20°C.

Catalog No. 50-200-8996


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