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LMK 235, R&D Systems™
SDP

Catalog No. 483010
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10 mg
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Catalog No. Quantity
48-301-0 10 mg
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Catalog No. 48-301-0 Supplier R&D Systems Supplier No. 4830/10

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Description

A Tocris product, part of R&D Systems. Selective HDAC4/HDAC5 inhibitor

Selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor (IC50 values are 4.22, 11.9, 55.7, 320, 852, 881, and 1278 nM for HDAC 5, 4, 6, 1, 11, 2, and 8, respectively). Demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 = 0.49 and 0.32 μM respectively).

Chemical Identifiers

CAS 1418033-25-6
Molecular Formula C15H22N2O4
Molecular Weight (g/mol) 294.35
MDL Number MFCD26522892
InChI Key VRYZCEONIWEUAV-UHFFFAOYSA-N
Synonym 6-3,5-dimethylphenyl formamido oxy-n-hydroxyhexanamide, n-6-hydroxyamino-6-oxohexyl oxy-3,5-dimethylbenzamide, n-5-hydroxycarbamoyl pentoxy-3,5-dimethylbenzamide, n-6-hydroxyamino-6-oxo-hexoxy-3,5-dimethyl-benzamide, n-6-hydroxyamino-6-oxohexyl oxy-3,5-dimethyl-benzamide
PubChem CID 71520717
IUPAC Name 6-{[(3,5-dimethylphenyl)formamido]oxy}-N-hydroxyhexanamide
SMILES CC1=CC(=CC(C)=C1)C(=O)NOCCCCCC(=O)NO

Specifications

Quantity 10 mg
Formula Weight 294.35
Percent Purity >98%
Product Line Tocris
Chemical Name or Material LMK 235

Safety and Handling

Recommended Storage Store at -20°C
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