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Invitrogen™ LNX1 Polyclonal Antibody
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Catalog No. PI720003
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100 μg
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Catalog No. Quantity
PI720003 100 μg
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Catalog No. PI720003 Supplier Invitrogen™ Supplier No. 720003
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Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with Monkey, Rat, Mouse and Goat.

Lnx1 (Ligand of Numb Protein X 1) protein is encoded by the Lnx1 gene located on chromosome 4 in humans and is known as PDZRN2 (PDZ domain-containing RING finger 2). It is through its RING finger and PDZ domains that Lnx1 forms oligomers and interacts with some of its target proteins such as JAM4 to form multiprotein complexes. Lnx1 is best studied as a E3 ubiquitin ligase that also contains the NPXY motifs which allows binding to the Phosphotyrosine binding domain (PTB) on Numb protein. This interaction has been shown to be responsible for ubiquitination of Numb, which prevents the proteasomal degradation of Notch intracellular domain (NICD) and thus positively regulates the Notch signaling pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LNX1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA, 30% glycerol and 0.09% sodium azide; pH 7.2
Gene LNX1
Gene Accession No. O70263, Q8TBB1
Gene Alias E3 ubiquitin-protein ligase LNX; Ligand of Numb protein X 1; ligand of Numb-binding protein 1; Ligand of Numb-protein X 1; ligand of numb-protein X 1, E3 ubiquitin protein ligase; LNX; Lnx1; MPDZ; multi-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNX; numb-binding protein 1; PDZ domain-containing RING finger protein 2; PDZRN2; RING-type E3 ubiquitin transferase LNX; UNQ574/PRO1136
Gene Symbols LNX1
Host Species Rabbit
Immunogen Multiple peptides against Human LNX1 (aa 200-213, 704-719).
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16924, 360926, 84708
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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