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Apexbio Technology LLC VPS34-IN1 1383716-33-3 100mg
SDP

Supplier:  Apexbio Technology LLC B6179100

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VPS34-IN1 (CAS 1383716-33-3) is a highly selective small molecule inhibitor of the class III phosphoinositide 3-kinase Vps34 exhibiting an in vitro IC50 of 25 nM Vps34 is responsible for phosphorylation of phosphatidylinositol to generate PtdIns(3)P which coordinates membrane trafficking through recruitment of PX and FYVE domain-containing proteins VPS34-IN1 potently inhibits Vps34 without significantly affecting more than 340 protein kinases or 25 lipid kinases including all class I and II PI3K isoforms Cellular studies show VPS34-IN1 induces rapid dose-dependent dispersion of PtdIns(3)P-binding probes and diminishes SGK3 phosphorylation aiding in the elucidation of Vps34 signaling and PI3K pathway interactions in cellular models

Catalog No. 50-000-92134


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