AdipoGen LPS (Universal) from S. abortus equi (S-form) TLRpure Sterile Solution (1 mg)

Supplier:  AdipoGen IAX100009M001

LPS (Universal) from S. abortus equi (S-form) TLRpure Sterile Solution (1 mg), Adipogen Life Sciences. Chemical. Isolated and purified from Salmonella abortus equi. Activation of cells by LPS is mediated by the Toll-like receptor 4 (TLR4). For optimal interaction with LPS, TLR4 requires association with myeloid differentiation protein 2 (MD-2). According to current consensus activation of TLR4 is preceded by the transfer of LPS to membrane-bound (m) or soluble (s) CD14 by LPS-binding protein (LBP). Re-form LPS and lipid A, but not S-form LPS, are capable of inducing TNF-alpha responses also in the absence of CD14. LPS, synthesized by most wild-type (WT) Gram-negative bacteria (S-form LPS), consists of three regions, the O-polysaccharide chain, which is made up of repeating oligosaccharide units, the core oligosaccharide and the lipid A, which harbors the endotoxic activity of the entire molecule.

Catalog No. 50-168-7721