Invitrogen™ LRAT Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599243

Catalog No. PIPA599243

Description

Antibody detects endogenous levels of total LRAT.

Lecithin retinol acyltransferase (LRAT) is a membrane bound enzyme that catalyzes the transfer of an acyl group from the sn-1 position of lecithin to vitamin A which generates all-trans-retinyl esters (tREs) in the liver, some extrahepatic tissues, such as the lung, and retinal pigmented epithelium. LRAT can also exchange palmitoyl groups between RPE65, a tRE binding protein essential for vision, and tREs, which is important for the operation of the visual pathway. LRAT is essential for the dietary mobilization, transport, and storage of vitamin A as well as the synthesis of the visual pigment chromophore. LRAT monomers interact in membranes to form homodimers through disulfide bond formation. A loss of LRAT correlates with an early onset severe retinal dystrophy and severe retinyl ester deprivation, while a reduction in LRAT expression may be associated with invasive bladder cancer.

Specifications

• Antigen: LRAT
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LRAT
• Gene Alias: 1300010A18Rik; AI449251; LCA14; Lecithin retinol acyltransferase; lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase); lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase); Lrat; Phosphatidylcholine--retinol O-acyltransferase; phosphatidylcholine-retinol-O-acyltransferase
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 64047, 79235, 9227
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O95237, Q9JI60, Q9JI61
• Gene Symbols: LRAT
• Immunogen: A synthesized peptide derived from human LRAT(Accession O95237), corresponding to amino acid residues Y118-C168.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov