Invitrogen™ LRRC33 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5107197

Catalog No. PIPA5107197

Description

Sequence homology: Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%.

LRRC33 is a key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. It associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. It is able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta and controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3).

Specifications

• Antigen: LRRC33
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NRROS
• Gene Alias: E430025L02Rik; ELLP3030; Garpl1; leucine rich repeat containing 33; leucine-rich repeat-containing protein 33; Leucine-rich repeat-containing protein 33^; Lrcc33; Lrrc33; negative regulator of reactive oxygen species; Nrros; RGD1310771; Transforming growth factor beta activator LRRC33; UNQ3030; UNQ3030/PRO9833
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 375387
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q86YC3
• Gene Symbols: NRROS
• Immunogen: Synthetic peptide directed towards the N terminal region of human LRRC33.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov