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Invitrogen™ LRRC4 Polyclonal Antibody
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Catalog No. PIPA578649
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100 μL
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PIPA578649 100 μL
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Catalog No. PIPA578649 Supplier Invitrogen™ Supplier No. PA578649
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Description

Rabbit Polyclonal Antibody

Positive Control: m brain, brain Predicted Reactivity: Human (98%), Rhesus Monkey (98%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The LRRC4 gene, also known as netrin-G ligand 2 (NGL-2), is a brain-specific member of the leucine-rich repeat superfamily, playing a critical role in the central nervous system. Its expression is particularly high in areas such as the hippocampal CA1 and CA2 regions, as well as in granule cells of the dentate gyrus. LRRC4 is a known tumor suppressor gene associated with glioma suppression, as it regulates glioma cell growth, angiogenesis, and invasion through extensive signaling networks. It can participate in multiphase loops involving miRNA, transcription factors, and gene methylation modifications. This gene targets various genes involved in cell motility, impacting glioblastoma cell movement and polarization by binding to enhancer elements and activating transcription, notably the RAP1GAP gene. Its function and expression are crucial in maintaining normal brain function and hold potential implications in the management of gliomagenesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LRRC4
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Lrrc4
Gene Accession No. Q45R42, Q99PH1
Gene Alias BAG; brain tumor associated protein LRRC4; brain tumor-associated protein BAG; Brain tumor-associated protein MBAG1; leucine rich repeat containing 4; leucine rich repeat containing 4 protein; leucine-rich repeat-containing 4; leucine-rich repeat-containing protein 4; LIBG-like protein; LRRC4; LRRC4-like protein; MBAG1; NAG14; Nasopharyngeal carcinoma-associated gene 14 protein; netrin-G2 ligand; NGL-2; NLG2; NLG-2; protein NGL-2; UNQ554/PRO1111
Gene Symbols Lrrc4
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the Intracellular domain of mouse LRRC4. The exact sequence is proprietary.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 192198, 641521
Target Species Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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