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Apexbio Technology LLC Luotonin A 205989-12-4 1mg
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Supplier:  Apexbio Technology LLC C44331

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Luotonin A (CAS 205989-12-4) is a small-molecule inhibitor targeting human topoisomerase I It is designed to stabilize the topoisomerase I-DNA binary complex thereby interfering with DNA processing pathways Luotonin A exerts its biological activity primarily through inhibition of DNA strand religation promoting the accumulation of topoisomerase I-linked DNA breaks and inducing topoisomerase I-dependent cytotoxicity In in vitro studies Luotonin A demonstrates inhibitory activity with an IC50 value of approximately 1 8 g/mL in P-388 cells Based on these pharmacological properties Luotonin A holds research potential in cancer research to investigate topoisomerase I-mediated pathways and DNA damage response

Catalog No. 50-000-91624


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