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LXR-alpha Polyclonal Antibody, Active Motif™
SDP

Catalog No. 501993207
Encompass
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50-199-3207 10 μL
50-199-3206 100 μL
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Catalog No. 50-199-3207 Supplier Active Motif Supplier No. 61176
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Description

Rabbit Polyclonal Antibody

NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.

Specifications

Antigen LXR-alpha
Applications ChIP Assay, ChIP sequencing (ChIP-seq), Western Blot
Classification Polyclonal
Concentration Lot-Specific
Conjugate Unconjugated
Formulation PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene NR1H3
Gene Accession No. Q13133, Q9Z0Y9
Gene Alias AU018371; liver X nuclear receptor alpha variant 1; Liver X receptor alpha; LXR; LXR alpha; LXRA; LXR-a; LXRalpha; LXRb; NER; NERI; NR1H2; Nr1h3; nuclear orphan receptor LXR-alpha; nuclear oxysterol receptor LxR-alpha; Nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; Oxysterols receptor LXR-alpha; RLD1; RLD-1; ubiquitously-expressed nuclear receptor 1; Unr1
Gene Symbols NR1H3
Host Species Rabbit
Immunogen This LXR-alpha antibody was raised against a peptide in the N-terminal region of human LXR-alpha.
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10062, 22259
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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