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LXR-alpha Rabbit anti-Human, Mouse, Unconjugated, Polyclonal, Active Motif™ 
Rabbit Polyclonal Antibody
$135.30 - $546.00
Specifications
| Monoclonal or Polyclonal | Polyclonal |
|---|---|
| Primary or Secondary | Primary |
| Antigen | LXR-alpha |
| Conjugate | Unconjugated |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|
50-199-3207
|
Active Motif
61176 |
10 μL |
Each for $135.30
|
|
50-199-3206
|
Active Motif
61175 |
100 μL |
Each for $546.00
|
|
Description
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.Specifications
| Polyclonal | |
| Primary | |
| LXR-alpha | |
| Unconjugated |
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