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LXR-alpha Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
$156.65 - $638.65
Specifications
| Antigen | LXR-alpha |
|---|---|
| Concentration | Lot-Specific |
| Applications | ChIP Assay, ChIP sequencing (ChIP-seq), Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-199-3207
|
Active Motif
61176 |
10 μL |
Each for $156.65
|
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50-199-3206
|
Active Motif
61175 |
100 μL |
Each for $638.65
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Description
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.Specifications
| LXR-alpha | |
| ChIP Assay, ChIP sequencing (ChIP-seq), Western Blot | |
| Unconjugated | |
| Rabbit | |
| Human, Mouse | |
| Q13133, Q9Z0Y9 | |
| 10062, 22259 | |
| This LXR-alpha antibody was raised against a peptide in the N-terminal region of human LXR-alpha. | |
| Primary | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| NR1H3 |
| Lot-Specific | |
| Polyclonal | |
| Liquid | |
| RUO | |
| PBS with 30% glycerol and 0.035% sodium azide; pH 7.5 | |
| AU018371; liver X nuclear receptor alpha variant 1; Liver X receptor alpha; LXR; LXR alpha; LXRA; LXR-a; LXRalpha; LXRb; NER; NERI; NR1H2; Nr1h3; nuclear orphan receptor LXR-alpha; nuclear oxysterol receptor LxR-alpha; Nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; Oxysterols receptor LXR-alpha; RLD1; RLD-1; ubiquitously-expressed nuclear receptor 1; Unr1 | |
| NR1H3 | |
| IgG | |
| Antigen affinity chromatography | |
| Antibody |
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