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  5. Tocris Bioscience™ LY 2603618

Tocris Bioscience™ LY 2603618
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Catalog No. 645410
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective Chk1 inhibitor (IC50 = 7 nM)

LY 2603618 is a potent and selective Chk1 inhibitor (IC50 = 7 nM). Inhibits Chk1 autophosphorylation. Induces cell cycle arrest in the G2/M phase and induces the DNA damage response in lung cancer cells. Inhibits growth of NSCLC xenografts in mice when administered in combination with Pemetrexed (Cat.No. 6185).

Specifications

Chemical Name or Material N-[5-Bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy)phenyl]-N'-(5-methyl-2-pyrazinyl)urea
CAS 911222-45-2
Quantity 10 mg
Molecular Formula C18H22BrN5O3
Formula Weight 436.3
Purity 98%
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