Tocris™ LY 2886721 Hydrochloride

Catalog No. 70-815-0

Supplier: Tocris™ 7081/50

Description

Potent and selective β-secretase (BACE) inhibitor

LY 2886721 Hydrochloride is a potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Aβ1-40 and Aβ1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Aβ and sAPPβ levels in an Alzheimer's disease mouse model.

Greener Choice Claims

• Environmental benefits include:
• Ozone-Safe or Safe for the Ozone Layer

Specifications

• Chemical Name or Material: N-[3-[(4 AS,7 AS)-2-Amino-4 A,5-dihydro-4 H-furo[3,4-d][1,3 ]thiazin-7 A(7 H)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride
• CAS: 1262036-49-6
• Quantity: 50 mg
• Target: Additional Synthetic Protease Inhibitors
• Molecular Formula: C₁₈H₁₆F₂N₄O₂S.HCl
• Purity: 0.98