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Tocris™ LY 2886721 Hydrochloride
Potent and selective β-secretase (BACE) inhibitor
Supplier: Tocris™ 7081/10
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Description
LY 2886721 Hydrochloride is a potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Aβ1-40 and Aβ1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Aβ and sAPPβ levels in an Alzheimer's disease mouse model.Specifications
| N-[3-[(4 AS,7 AS)-2-Amino-4 A,5-dihydro-4 H-furo[3,4-d][1,3 ]thiazin-7 A(7 H)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride | |
| 10 mg | |
| C18H16F2N4O2S.HCl |
| 1262036-49-6 | |
| Additional Synthetic Protease Inhibitors | |
| 0.98 |
Safety and Handling
Recommended Storage : Store at -20°C
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