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LY 364947, R&D Systems™
SDP

Catalog No. 27181
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27-181 1 mg
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Catalog No. 27-181 Supplier R&D Systems Supplier No. 2718/1

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Description

A Tocris product, part of R&D Systems. Selective inhibitor of TGF-βRI

Selective inhibitor of TGF-β type-I receptor (TGF-β RI, TGFR-I, TβR-I, ALK-5) (IC50 values are 59, 400 and 1400 nM for TGR-β RI, TGF-β RII and MLK-7K respectively). Inhibits TGF-β-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC50 values are 47 and 89 nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.

Chemical Identifiers

CAS 396129-53-6
Molecular Formula C17H12N4
Molecular Weight (g/mol) 272.311
InChI Key IBCXZJCWDGCXQT-UHFFFAOYSA-N
Synonym tbetar-i inhibitor, 4-3-pyridin-2-yl-1h-pyrazol-4-yl quinoline, alk5 inhibitor i, tgf-beta ri kinase inhibitor, 4-5-pyridin-2-yl-1h-pyrazol-4-yl quinoline, transforming growth factor-beta type i receptor kinase inhibitor, 4-3-pyridin-2-yl 1h-pyrazol-4-yl quinoline, 3-pyridin-2-yl-4-4-quinonyl-1h-pyrazole
PubChem CID 447966
IUPAC Name 4-(5-pyridin-2-yl-1H-pyrazol-4-yl)quinoline
SMILES C1=CC=C2C(=C1)C(=CC=N2)C3=C(NN=C3)C4=CC=CC=N4

Specifications

Quantity 1 mg
Formula Weight 272.31
Percent Purity >99%
Product Line Tocris
Chemical Name or Material LY 364947

Safety and Handling

Recommended Storage Store at Room Temperature
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