Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Organoheterocyclic compounds
  6. Azoles
  7. Pyrazoles
  8. LY 364947, Tocris Bioscience™

LY 364947, Tocris Bioscience™

Catalog No. 27181
Change view
Click to view available options
Quantity:
1 mg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
27-181 1 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
This item is not returnable. View return policy
Catalog No. 27-181 Supplier R&D Systems Supplier No. 2718/1
This item is not returnable. View return policy

Description

Selective inhibitor of TGF-βRI

Selective inhibitor of TGF-β type-I receptor (TGF-β RI, TGFR-I, TβR-I, ALK-5) (IC50 values are 59, 400 and 1400 nM for TGR-β RI, TGF-β RII and MLK-7K respectively). Inhibits TGF-β-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC50 values are 47 and 89 nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.

Chemical Identifiers

CAS 396129-53-6
Molecular Formula C17H12N4
Molecular Weight (g/mol) 272.311
InChI Key IBCXZJCWDGCXQT-UHFFFAOYSA-N
Synonym tbetar-i inhibitor, 4-3-pyridin-2-yl-1h-pyrazol-4-yl quinoline, alk5 inhibitor i, tgf-beta ri kinase inhibitor, 4-5-pyridin-2-yl-1h-pyrazol-4-yl quinoline, transforming growth factor-beta type i receptor kinase inhibitor, 4-3-pyridin-2-yl 1h-pyrazol-4-yl quinoline, 3-pyridin-2-yl-4-4-quinonyl-1h-pyrazole
PubChem CID 447966
IUPAC Name 4-(5-pyridin-2-yl-1H-pyrazol-4-yl)quinoline
SMILES C1=CC=C2C(=C1)C(=CC=N2)C3=C(NN=C3)C4=CC=CC=N4

Specifications

Quantity 1 mg
Formula Weight 272.31
Percent Purity >99%
Chemical Name or Material LY 364947

Safety and Handling

Recommended Storage Store at Room Temperature
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.