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  6. Invitrogen™ Ly-49G2 Monoclonal Antibody (eBio4D11 (4D11)), FITC, eBioscience™, Invitrogen™ 

Invitrogen™ Ly-49G2 Monoclonal Antibody (eBio4D11 (4D11)), FITC, eBioscience™, Invitrogen™
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Catalog No. 509851
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100 μg
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Catalog No. Quantity
50-985-1 100 μg
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Catalog No. 50-985-1 Supplier Invitrogen™ Supplier No. 11578182
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Description

Rat Monoclonal Antibody

Description: The 4D11 monoclonal antibody reacts with Ly-49G2 (also known as LGL-1). The Ly-49 family of NK-cell receptors, members of the C-type lectin superfamily, are disulfide-linked type-II transmembrane protein homodimers with extracellular carbohydrate recognition domains, which bind to MHC class I alloantigens. The Ly-49 family members are expressed independently, such that an individual NK or T cell may display more than one class of Ly-49 receptor. Ly-49G2 is an inhibitory receptor expressed on subsets of natural killer (NK) cells, NK-T cells (in all strains tested), and on a population of memory CD8+ T cells (in C57BL/6 mice). The 4D11 antibody has been reported to cross react with the Ly-49AB6, Ly-49ABALB, and Ly-49T129/J inhibitory receptors and Ly-49LCBA/J activatingreceptors. The proportion of NK-T cells expressing Ly-49A and Ly-49G2 is higher in the thymus than in liver, and there is evidence that down-regulation of Ly-49 receptor expression is necessary for normal NK-T-cell development to occur. Applications Reported: This eBio4D11 (4D11) antibody has been reported for use in flow cytometric analysis. Applications Tested: This eBio4D11 (4D11) antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL.

Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells, while allowing them to attack infected or transformed cells in which class I molecules have been down-regulated. These inhibitory receptors are also expressed on subpopulations of mouse CD8+ T cells.
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Specifications

Antigen Ly-49G2
Applications Flow Cytometry
Classification Monoclonal
Clone eBio4D11 (4D11)
Concentration 0.5 mg/mL
Conjugate FITC
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Klra7
Gene Accession No. Q60654
Gene Alias Killer cell lectin-like receptor 7; killer cell lectin-like receptor, subfamily A, member 7; Klra7; LGL-1; Ly49g; ly-49g; Ly49-g; Ly-49G.1; Ly-49G.2; Ly-49G.3; Ly49G.4; Ly49g1; Ly49g2; Ly49g4; Lymphocyte antigen 49g; T-cell surface glycoprotein Ly-49G
Gene Symbols Klra7
Host Species Rat
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16638
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov

For Research Use Only.

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